| Thursday September 7, 2023 |
| 14:15 | Registration |
|
| 15:15 | Welcome and Opening |
Dr Maja BEUS (DUKE UNIVERSITY, Durham, United States)
Dr Hrvoje RIMAC (SELVITA, Zagreb, Croatia) |
| 15:30 | KL01 - Druggability Beyond the Rule of Five |
Dr Sanja KOSTRUN
(SELVITA LTD., Zagreb, Croatia) |
| 16:00 | EFMC-YMCS Competition Presentation Session I |
|
| Session Chair |
Dr Hrvoje RIMAC
(SELVITA, Zagreb, Croatia) |
| 16:00 | OC01 - Shedding Light on L-Type Calcium Channels with Novel Far-Red Fluorescent Ligands
Winner of the young medicinal chemist meeting in Belgium (KVCV) |
Mrs Carlotta BORGARELLI
(KU LEUVEN, Heverlee, Belgium) |
| 16:15 | OC02 - Biophysical Screening for the Identification of Small Molecules as Lactate Dehydrogenase (LDHS)’s Oligomeric State Disruptors
Winner of the young medicinal chemist meeting in Belgium (SRC) |
Mrs Chiara BRUSTENGA
(UCL/LDRI, Bruxelles, Belgium) |
| 16:30 | OC03 - Discovery of Allosteric Modulators of A2A Receptors
Winner of the young medicinal chemist meeting in Croatia |
Ms Tana TANDARIC
(RUDER BOSKOVIC INSTITUTE, Zagreb, Croatia) |
| 16:45 | OC04 - Molecular Sensing and Imaging of Carbon Dioxide Incomplex Environments
Winner of the young medicinal chemist meeting in Israel |
Dr Ori GREEN
(ETH ZURICH, Zürich, Switzerland) |
| 17:00 | Flash Poster Presentations (Part I) |
|
| FP01 – In Silico-Aided Optimization of Metallo Beta-Lactamase Inhibitors Active against Clinically Relevant Carbapenemases |
Dr Matteo BERSANI
(UNIVERSITÀ DEGLI STUDI DI TORINO, Torino, Italy) |
| FP02 – Voc’s Art: Voc-Based Probes for Exploration, Detection and Monitoring of Pathologies |
Ms Estelle BLOCHOUSE
(IC2MP CNRS, Poitiers, France) |
| FP03 – Using Chemical Modification of Anticancer Drug Scaffolds to Study Efflux Mediated Chemoresistance in Cancer Cells |
Mrs Madiha CHOWDHURY
(KINGS COLLEGE LONDON, London, United Kingdom) |
| FP04 – Semi-Synthesis of Thioglycoside Derivatives of the Natural Product Antibiotic Fidaxomicin |
Ms Isabella FERRARA
(UNIVERSITY OF ZURICH, Zurich, Switzerland) |
| FP05 – Carbamates as Potential New Drugs in the Treatment of Alzheimer’s Disease |
Dr Ana MATOSEVIC
( INSTITUTE FOR MEDICAL RESEARCH AND OCCUPATIONAL HEALTH (IMI), Zagreb, Croatia) |
| FP06 – GPR84 Structural-Functional Selectivity Relationship (SFSR) Reveals Distinct Responses Induced by Biased Agonists |
Mr Wang PINQI
(UNIVERSITY OF OXFORD, Oxford, United Kingdom) |
| FP07 – Design, Synthesis and in vitro Evaluation of New Peptide-Based Inhibitors Targeting Sars-Cov-2 Main Protease, Focusing on the Exploration of Heterocyclic Systems for the S3/S4 Sub-Pockets |
Dr Sara ROSSI
(UNIVERSITY OF SIENA, Grosseto, Italy) |
| FP08 – A Multistep High-Throughput Chemistry Platform to Take Protac Synthesis and Testing to a New Level |
Ms Rebecca STEVENS
(GSK/UNIVERSITY OF STRATHCLYDE, SHEFFORD, United Kingdom) |
| FP09 – Development of Dual-Functionalized Fluorophores to Monitor Antibody Delivery Systems |
Ms Tracey LUU
(MONASH UNIVERSITY, Parkville, Australia) |
| FP10 – Discovery of Potent Tetrazole Free Fatty Acid Receptor 2 Antagonists |
Ms Alice VALENTINI
(UNIVERSITY OF COPENHAGEN, Copenhagen, Denmark) |
| FP13 – Photoswitching HDAC Inhibitors for the Spatiotemporal Targeting of Cancer Cells with Light |
Dr Laia JOSA CULLERE
(INSTITUTE FOR ADVANCED CHEMISTRY OF CATALONIA (IQAC-CSIC), Barcelona, Spain) |
| 17:25 | Coffee Break & Exhibition |
|
| 17:45 | EFMC-YMCS Competition Presentation Session II |
|
| Session Chair |
Dr Michele MARI
(UNIVERSITY OF URBINO, Urbino, Italy) |
| 17:45 | OC05 - Optimization of a Pyridylpiperazine Series as a Novel Class of Efflux Pump Inhibitors in E. Coli to Fight Antimicrobial Resistance
Winner of the young medicinal chemist meeting in France (SCT) |
Ms Nina COMPAGNE
(INSERM U1177 DRUGS AND MOLECULES FOR LIVING SYSTEMS, Lille, France) |
| 18:00 | OC06 - Ga(III) Siderophore Complexes - A Metallo-Trojan Horse Strategy to Tackle Antimicrobial Resistance
Winner of the young medicinal chemist meeting in Ireland |
Mr Lewis MORE O'FERRALL
(ROYAL COLLEGE OF SURGEONS, Dublin, Ireland) |
| 18:15 | OC07 - Discovery of Isoquinoline Sulfonamides as Gyrase Inhibitors Active against Fluoroquinolone-Resistant Bacteria
Winner of the young medicinal chemist meeting in The Netherlands |
Dr Alexander BAKKER
(LEIDEN UNIVERSITY, 's-Gravenhage, The Netherlands) |
| 18:30 | OC08 - Design Principles for Cyclin K Molecular Glue Degraders
Winner of the 2023 EFMC-YSN PhD Prize |
Mrs Zuzanna KOZICKA
(FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH, Basel, Switzerland) |
| 18:45 | EFMC-YSN Soft Skills Training (1) - Reaxys Workshop: A Tandem Tour to Unveil the Profile of An Active Molecule |
Dr Giulia MONCELSI
(ELSEVIER LIFE SCIENCES, Amsterdam, The Netherlands) |
| 19:30 | EFMC-YMCS Poster Presentation Session 1 |
|
| 20:45 | EFMC-YSN Networking Event |
|
| 22:00 | End of the Day |
|
| Friday September 8, 2023 |
| 08:30 | EFMC-YSN Soft Skills Training (2) - Career Panel Discussion |
Dr Kristina GONCHARENKO (ZIFO RND SOLUTIONS, Basel, Switzerland)
Dr Sanja KOSTRUN (SELVITA LTD., Zagreb, Croatia)
Mr Patrik NIKOLIC (OPTIBRIUM, Cambridge, United Kingdom)
Dr David PERALTA (CHEMMEDCHEM/CHEMISTRY EUROPE, Weinheim, Germany)
Dr Minh Thao TRAN (JANSSEN PHARMACEUTICA, Beerse, Belgium)
Dr Chiara BORSARI (UNIVERSITY OF MILAN, Milan, Italy) |
| 09:30 | EFMC-YMCS Competition Presentation Session III |
|
| Session Chair |
Ms Floriane ESHAK
(UNIVERSITY PARIS CITÉ, Paris, France) |
| 09:30 | KL02 - Leveraging Natural Products to Afford New Therapeutic Leads That Can Target Resistant Tumors |
Prof. Thomas POULSEN
(AARHUS UNIVERSITY, Aarhus C, Denmark) |
| 10:00 | OC09 - Synthesis of Quinazoline Derivatives as Anticancer Agents
Winner of the young medicinal chemist meeting in Greece |
Dr Eleftheria GEORGIOU
(NKUA, Athens, Greece) |
| 10:15 | OC10 - Synthesis and Cytotoxic Activity of Novel Sclareol Derivatives
Winner of the young medicinal chemist meeting in Serbia |
Mr Pavle A. STOJKOVIC
(UNIVERSITY OF BELGRADE, Beograd, Serbia) |
| 10:30 | OC11 - From Pan to Pi3Kα-Selective Inhibitors: A Covalent Strategy to Fine-Tune Isoform-Specific Targeting
Winner of the young medicinal chemist meeting in Italy |
Dr Chiara BORSARI
(UNIVERSITY OF MILAN, Milan, Italy) |
| 10:45 | OC12 - Heterobifunctional E3 Ligase Recruiters Enable Pan-Degradation of Inhibitor of Apoptosis Proteins
Winner of the young medicinal chemist meeting in Slovenia |
Mrs Alesa BRICELJ
(UNIVERSITY OF LJUBLJANA, FACULTY OF PHARMACY, Ljubljana, Slovenia) |
| 11:00 | Flash Poster Presentations (Part II) |
|
| FP11 – Design and Synthesis of Novel RNA Ligands as Inhibitors of Oncogenic Micrornas Production |
Mr Jihed AZZOUZ
(INSTITUT DE CHIMIE DE NICE-ICN, Nice, France) |
| FP12 – Synthesis Optimization of the First in Class 3CLPRO Inhibitor Nirmatrelvir |
Mrs Anastasia FERRARO
(UNIVERSITÀ DEGLI STUDI DI NAPOLI FEDERICO II, Napoli, Italy) |
| FP15 – Aminoacrylamides with Potential Anti-Breast Cancer Activity Act Through 14-3-3σ/Er-Α PPI Stabilization |
Dr Paulo PITASSE SANTOS
(UNIVERSITY OF LEICESTER, Leicester, United Kingdom) |
| FP16 – Development of First-In-Class Dual LSD1-PRMT5 Inhibitors for the Treatment of Acute Myeloid Leukemia |
Ms Alessia RAUCCI
(SAPIENZA UNIVERSITY OF ROME, Rome, Italy) |
| FP17 – Design, Development and Evaluation of Novel Anticancer Drugs Targeting Protein Kinase D2 (Pkd2) |
Ms Lauren VOETS
(KU LEUVEN RESEARCH AND DEVELOPMENT, Leuven, Belgium) |
| FP18 – Novel Activators of Slack Potassium Channels for the Treatment of Histamine-Independent and Chronic Itch |
Mr Wenxin Felix ZHU
(GOETHE UNIVERSITÄT FRANKFURT, Frankfurt, Germany) |
| FP19 – Synthesis, Photochemistry and Biological Activity of Novel Bodipy Photochages as Potential Anticancer Phototherapeutics |
Ms Katarina ZLATIC
(RUDER BOSKOVIC INSTITUTE, Zagreb, Croatia) |
| 11:25 | Coffee Break & Exhibition |
|
| 11:45 | EFMC-YMCS Competition Presentation Session IV |
|
| Session Chair |
Dr Isabella ROMEO
(MAGNA GRÆCIA UNIVERSITY, Catanzaro, Italy) |
| 11:45 | OC13 - Peroxide-Cleavable Linkers for Antibody-Drug Conjugates
Winner of the young medicinal chemist meeting in United Kingdom |
Mrs Nicola ASHMAN
(UNIVERSITY OF CAMBRIDGE, Cambridge , United Kingdom) |
| 12:00 | OC14 - Accelerating Mechanistic Deconvolution Using Chemical Biological Tools
Winner of the young medicinal chemist meeting in Denmark |
Mr Esben BJERREGAARD SVENNINGSEN
(AARHUS UNIVERSITY, Aarhus C, Denmark) |
| 12:15 | OC15 - Novel 5-Ht6 Receptor Inverse Agonists and Neutral Antagonists Derived from 2-Arylpyrrole: Sustainable Synthesis and Pharmacological Profiling
Winner of the young medicinal chemist meeting in Poland |
Dr Marcin DROP
(JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE, Krakow, Poland) |
| 12:30 | OC16 - Styrylbenzothiazole Photoswitches for Spatiotemporal Control over Microtubule-Dependent Biology
Winner of the young medicinal chemist meeting in Germany |
Mr Li GAO
(ROCHE, Penzberg, Germany) |
| 12:45 | Lunch, Networking & Exhibition |
|
| 13:30 | EFMC-YMCS Poster Presentation Session 2 |
|
| 14:45 | EFMC-YMCS Competition Presentation Session V |
|
| Session Chair |
Dr Kristina GONCHARENKO
(ZIFO RND SOLUTIONS, Basel, Switzerland) |
| 14:45 | OC17 - Antimicrobial Photodynamic Therapy Combined with Antimicrobials: an Alternative Approach for Eradication of Gram-Negative Bacteria
Winner of the young medicinal chemist meeting in Portugal |
Mr Rafael AROSO
(UNIVERSIDADE DE COIMBRA, Coimbra, Portugal) |
| 15:00 | OC18 - Hitting a New Combination of Biological Targets to Cope with Alzheimer’s Disease
Winner of the young medicinal chemist meeting in Spain |
Ms Noemí MARTÍNEZ CONDE
(UNIVERSITY OF BARCELONA, Barcelona, Spain) |
| 15:15 | OC19 - Cyclic Tetrapeptides: Novel Remedy for Lead Poisoning
Winner of the young medicinal chemist meeting in Switzerland |
Mrs Tagwa MOHAMMED
(UNIVERSITY OF ZURICH, Zurich, Switzerland) |
| 15:30 | OC20 - Redox Probes and Bioreductive Prodrugs
Winner of the 2023 Symeres PhD Prize for Excellence in Chemistry in Life Sciences Research |
Dr Jan G. FELBER
(UNIVERSITÄT MÜNCHEN, München, Germany) |
| 15:45 | Voting Break |
|
| 16:00 | KL03 - Trends in Medicinal Chemistry and Chemical Biology |
Dr Yves P. AUBERSON
(NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, Basel, Switzerland) |
| 16:30 | Closing and Award Ceremony |
|
| 16:50 | End of the Symposium |
|
