EFMC-ASMC 2023

IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry

 Zagreb, Croatia    September 3-7, 2023

Opening lecture

Opening Lecture
Synthetic and Medicinal Chemistry for Biologics (IL01)

Prof. Jeffrey BODE
Prof. Jeffrey BODE
ETH ZURICH, Zürich, Switzerland
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EFMC Prizes

EFMC Prize for a Young Medicinal Chemist or Chemical Biologist in Industry
Discovery and Characterization of Potent, Efficacious and Orally Available Antimalarial Plasmepsin X Inhibitors (PR02)

Dr Teresa DE HARO GARCIA
Dr Teresa DE HARO GARCIA
UCB, Braine l'Alleud, Belgium

EFMC Prize for a Young Medicinal Chemist or Chemical Biologist in Academia
Targeted Protein Degradation via Molecular Glues (PR01)

Dr Georg WINTER
Dr Georg WINTER
RESEARCH CENTER FOR MOLECULAR MEDICINE OF THE AUSTRIAN ACADEMY OF SCIENCES, Vienna, Austria

Invited lectures

Synthesis of Fluorinated Molecules Using Modern Synthetic Tools (IL04)

Dr Tatiana BESSET
Dr Tatiana BESSET
INSA OF ROUEN, Mont-Saint-Aignan, France
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MicroCycle: A Machine Learning Driven, Automated and Integrated Platform for Drug Discovery (IL03)

Dr Cara BROCKLEHURST
Dr Cara BROCKLEHURST
NOVARTIS, Basel, Switzerland
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Next Generation Design-Make-Test-Analysis-Cycles (IL14)

Dr Clara CHRIST
Dr Clara CHRIST
BAYER, Berlin, Germany
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Making Difficult-to-Make Molecules: Photochemistry as an Enabling Tool (IL25)

Dr Susannah COOTE
Dr Susannah COOTE
UNIVERSITY OF BATH, Bath, United Kingdom
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Will Chemputers Dream of Electric Drugs (IL23)

Prof. Leroy CRONIN
Prof. Leroy CRONIN
UNIVERSITY OF GLASGOW, Glasgow, United Kingdom
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New Catalytic Approaches for Simplifying Complex Amine Synthesis (IL06)

Prof. Darren J. DIXON
Prof. Darren J. DIXON
UNIVERSITY OF OXFORD, Oxford, United Kingdom
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Taking Molecular Glue Degraders to New Heights (IL24)

Dr Etienne DONCKELE
Dr Etienne DONCKELE
MONTE ROSA THERAPEUTICS, Basel, Switzerland
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Making and Breaking of C-S Bonds Using Metal Catalysis (IL15)

Dr Ivana FLEISCHER
Dr Ivana FLEISCHER
UNIVERSITY OF TÜBINGEN, Tuebingen, Germany

Genochemetic Diversification of Natural Products (IL13)

Prof. Rebecca GOSS
Prof. Rebecca GOSS
UNIVERSITY OF ST ANDREWS, St Andrews, United Kingdom

Chemical Probes and their Relevance for Drug Discovery Programs – Examples from the Endocannabinoid System (IL05)

Dr Uwe GRETHER
Dr Uwe GRETHER
F. HOFFMANN-LA ROCHE, Basel, Switzerland
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Novel Modes of Enzyme Inhibition (IL26)

Dr Anders JOHANSSON
Dr Anders JOHANSSON
ASTRAZENECA, Molndal, Sweden
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Multicomponent Alkene Cross-Coupling by Base Metal Catalysis (IL20)

Dr Ming Joo KOH
Dr Ming Joo KOH
NATIONAL UNIVERSITY OF SINGAPORE, Singapore, Singapore

The beautiful simplicity of rearrangements – towards ideal reactions? (IL10)
Chemistry Europe Speaker

Prof. Nuno MAULIDE
Prof. Nuno MAULIDE
UNIVERSITY OF VIENNA, Vienna, Austria
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From BRD4 to KRAS: 12 Years of Oncology Small Molecules (IL16)

Dr Darryl MCCONNELL
Dr Darryl MCCONNELL
BOEHRINGER INGELHEIM, Austria
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Structure Based Identification of Novel Albumin Binders for Half-Life Extensions of Proteins and Peptides (IL11)

Dr Maria MÉNDEZ PÉREZ
Dr Maria MÉNDEZ PÉREZ
SANOFI-AVENTIS DEUTSCHLAND GMBH, Frankfurt, Germany
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Innovation in Synthetic Fluorine Chemistry through Use of Flow (IL02)

Prof. Timothy NOËL
Prof. Timothy NOËL
UNIVERSITY OF AMSTERDAM, Amsterdam, The Netherlands

Synthesis of Glycosylated Natural Products or Analogues of Biological Interest (IL17)

Dr Stéphanie NORSIKIAN
Dr Stéphanie NORSIKIAN
INSTITUT DE CHIMIE DES SUBSTANCES NATURELLES, Gif-sur-Yvette, France

Phenotypic Screen to NLRP3 lead (IL12)

Dr Daniel OEHLRICH
Dr Daniel OEHLRICH
JANSSEN RESEARCH AND DEVELOPMENT, Beerse, Belgium

Challenges and Opportunities in CNS Drug Discovery (IL07)

Dr Frauke POHLKI
Dr Frauke POHLKI
ABBVIE, Ludwigshafen, Germany

Covalent Chemical Biology with Natural Products and Novel Synthetic Warheads (IL19)

Prof. Thomas POULSEN
Prof. Thomas POULSEN
AARHUS UNIVERSITY, Aarhus C, Denmark
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Enabling Technologies to Drive the MSD Portfolio (IL08)

Dr Rebecca RUCK
Dr Rebecca RUCK
MERCK, SHARP & DOHME, Rahway, United States
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Empowering Organic Synthesis: From Unique Methods to Complex Natural Products (IL09)

Prof. David SARLAH
Prof. David SARLAH
UNIVERSITY OF ILLINOIS, Urbana, United States
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Novel, Reversible DCAF1 Ligands Expand the TPD-Toolbox (IL21)

Dr Martin SCHRÖDER
Dr Martin SCHRÖDER
NOVARTIS, Basel, Switzerland
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Dr Anna VULPETTI
Dr Anna VULPETTI
NOVARTIS, Basel, Switzerland
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Machine Learning to Accelerate Design-Make-Test Cycles (IL18)

Dr Marwin SEGLER
Dr Marwin SEGLER
MICROSOFT RESEARCH, Cambridge, United Kingdom

Natural Product Synthesis Through the Lens of Informatics (IL27)

Prof. Ryan SHENVI
Prof. Ryan SHENVI
SCRIPPS RESEARCH, La Jolla, United States

Disrupting the YAP-TEAD Protein-Protein Interaction with Small Molecules - Discovery of Drug Candidate NVP-IAG933 (IL22)

Dr Nicolas SOLDERMANN
Dr Nicolas SOLDERMANN
NOVARTIS, Basel, Switzerland

Oral Communications

Development of Selective mTOR Inhibitors for the Treatment of Cancer and Neurological Disorders (OC05)

Dr Chiara BORSARI
Dr Chiara BORSARI
UNIVERSITY OF MILAN, Milan, Italy

EFMC-YMCS 2022 Best Oral Communication (OC09)
Epitope Identification Using In-Silico Approaches, a Case Study: Nanobodies Binding to MGlu5 Receptor

Ms Floriane ESHAK
Ms Floriane ESHAK
UNIVERSITY PARIS CITÉ, Paris, France

Direct Access to Unnatural Drug-Like Molecules by Photocatalytic Late-Stage Functionalization (OC07)

Prof. Olga GARCIA MANCHENO
Prof. Olga GARCIA MANCHENO
UNIVERSITY OF MÜNSTER, Münster, Germany
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Isolation and Biological Activities of Natural Products and Analogues from the Adriatic Coral Eunicella Cavolini (OC02)

Prof. Dean MARKOVIC
Prof. Dean MARKOVIC
UNIVERSITY OF RIJEKA, Rijeka, Croatia
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High-Throughput Protac Synthesis and Direct to Biology Assaying for Rapidly Evaluating Targeted Protein Degradation (OC04)

Dr Afjal MIAH
Dr Afjal MIAH
GLAXOSMITHKLINE, Stevenage, United Kingdom
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RSC Medicinal Chemistry Lectureship
Time to Shine for Constrained Peptides in Medicinal Chemistry (OC11)

Prof. Christoph NITSCHE
Prof. Christoph NITSCHE
AUSTRALIAN NATIONAL UNIVERSITY, Canberra, Australia

Design and Optimization of High Performance KSPi ADCs With Increased Tumor Selectivity: Enhancing the Therapeutic Window by Legumain-Mediated ADC Activation (OC03)

Dr Anne-Sophie REBSTOCK
Dr Anne-Sophie REBSTOCK
VINCERX, Monheim am Rhein, Germany
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Discovery of Imidazo[1,2-a]Pyridine Carboxamide BAY 1165747, a Long-Acting Soluble Guanylate Cyclase Stimulator for Resistant Hypertension (OC06)

Dr Alexandros VAKALOPOULOS
Dr Alexandros VAKALOPOULOS
BAYER, Wuppertal, Germany
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Cocktails For 19F NMR Fragment Screening: From Theory to Applications Using Enamine’s Stock Chemical Space (OC08)

Prof. Dmytro VOLOCHNYUK
Prof. Dmytro VOLOCHNYUK
ENAMINE LTD, Kyiv, Ukraine
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First time disclosure
Discovery of the clinical candidate BI 1810631 (Zongertinib), a Selective HER2 Inhibitor for the Treatment of HER2 Exon 20 Insertion Driven Tumors (OC10)

Dr Birgit WILDING
Dr Birgit WILDING
BOEHRINGER INGELHEIM, Vienna, Austria
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Divergent Synthesis as an Emergent Tool for Drug Discovery (OC01)

Prof. Alexandros ZOGRAFOS
Prof. Alexandros ZOGRAFOS
ARISTOTLE UNIVERSITY OF THESSALONIK, THESSALONIKI, Greece
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