EFMC-ASMC 2023

IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry

 Zagreb, Croatia    September 3-7, 2023

Oral Communications

OC05 - Discovery of A Potent, Selective and Metabolically Stable mTOR Kinase Inhibitor Exploiting Morpholine Isosters

Dr Chiara BORSARI
Dr Chiara BORSARI
UNIVERSITY OF MILAN, Milan, Italy

EFMC Prize Winner EFMC-YMCS 2022

Ms Floriane ESHAK
Ms Floriane ESHAK
UNIVERSITY PARIS CITÉ, Paris, France

OC07 - Direct Access to Unnatural Drug-Like Molecules by Photocatalytic Late-Stage Functionalization

Prof. Olga GARCIA MANCHENO
Prof. Olga GARCIA MANCHENO
UNIVERSITY OF MÜNSTER, Münster, Germany
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OC02 - Isolation and Biological Activities of Natural Products and Analogues from the Adriatic Coral Eunicella Cavolini

Prof. Dean MARKOVIć
UNIVERSITY OF RIJEKA, Rijeka, Croatia

OC04 - High-Throughput Protac Synthesis and Direct to Biology Assaying for Rapidly Evaluating Targeted Protein Degradation

Dr Afjal MIAH
GLAXOSMITHKLINE, Stevenage, United Kingdom
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OC03 - Design and Optimization of High Performance KSPi ADCs With Increased Tumor Selectivity: Enhancing the Therapeutic Window by Legumain-Mediated ADC Activation

Dr anne-sophie REBSTOCK
VINCERX, monheim am rhein, Germany
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OC06 - Discovery of Imidazo[1,2-a]Pyridine Carboxamide BAY 1165747, a Long-Acting Soluble Guanylate Cyclase Stimulator for Resistant Hypertension

Dr Alexandros VAKALOPOULOS
BAYER AG, Wuppertal, Germany

OC08 - Cocktails For 19F NMR Fragment Screening: From Theory to Applications Using Enamine’s Stock Chemical Space

Prof. Dmytro VOLOCHNYUK
Prof. Dmytro VOLOCHNYUK
ENAMINE LTD, Kyiv, Ukraine
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OC01 - Divergent Synthesis as an Emergent Tool for Drug Discovery

Prof. Alexandros ZOGRAFOS
ARISTOTLE UNIVERSITY OF THESSALONIK, THESSALONIKI, Greece
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Opening lecture

Opening Lecture
Synthetic and Medicinal Chemistry for Biologics

Prof. Jeffrey BODE
Prof. Jeffrey BODE
ETH ZURICH, Zürich, Switzerland
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Invited lectures

Synthesis of Fluorinated Molecules Using Modern Synthetic Tools

Dr Tatiana BESSET
Dr Tatiana BESSET
INSA OF ROUEN, Mont-Saint-Aignan, France
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MicroCycle: A Machine Learning Driven, Automated and Integrated Platform for Drug Discovery

Dr Cara BROCKLEHURST
Dr Cara BROCKLEHURST
NOVARTIS, Basel, Switzerland
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Next Generation Design-Make-Test-Analysis-Cycles

Dr Clara CHRIST
Dr Clara CHRIST
BAYER, Berlin, Germany
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Making Difficult-to-Make Molecules: Photochemistry as an Enabling Tool

Dr Susannah COOTE
Dr Susannah COOTE
UNIVERSITY OF BATH, Bath, United Kingdom
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Why Chemputers Will Dream of Electric Drugs

Prof. Leroy CRONIN
Prof. Leroy CRONIN
UNIVERSITY OF GLASGOW, Glasgow, United Kingdom
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EFMC Prize for a Young Medicinal Chemist or Chemical Biologist in Industry

Dr Teresa DE HARO GARCIA
UCB, Braine l'Alleud, Belgium

New Catalytic Approaches for Simplifying Complex Amine Synthesis

Prof. Darren J. DIXON
Prof. Darren J. DIXON
UNIVERSITY OF OXFORD, Oxford, United Kingdom
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Making and Breaking of C-S Bonds Using Metal Catalysis

Dr Ivana FLEISCHER
Dr Ivana FLEISCHER
UNIVERSITY OF TÜBINGEN, Tuebingen, Germany

Precision Molecule Editing (a Game of Bio and Chemo-catalysis)

Prof. Rebecca GOSS
Prof. Rebecca GOSS
UNIVERSITY OF ST ANDREWS, St Andrews, United Kingdom

Chemical Probes and their Relevance for Drug Discovery Programs – Examples from the Endocannabinoid System

Dr Uwe GRETHER
Dr Uwe GRETHER
F. HOFFMANN-LA ROCHE, Basel, Switzerland
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Novel Modes of Enzyme Inhibition

Dr Anders JOHANSSON
Dr Anders JOHANSSON
ASTRAZENECA, Molndal, Sweden
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Multicomponent Alkene Cross-Coupling by Base Metal Catalysis

Dr Ming Joo KOH
Dr Ming Joo KOH
NATIONAL UNIVERSITY OF SINGAPORE, Singapore, Singapore

Can Chemistry Generate Biological Questions?

Prof. Nuno MAULIDE
Prof. Nuno MAULIDE
UNIVERSITY OF VIENNA, Vienna, Austria
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From BRD4 to KRAS: 12 Years of Oncology Small Molecules

Dr Darryl MCCONNELL
Dr Darryl MCCONNELL
BOEHRINGER INGELHEIM, Vienna, Austria
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Structure Based Identification of Novel Albumin Binders for Half-Life Extensions of Proteins and Peptides

Dr Maria MÉNDEZ PÉREZ
Dr Maria MÉNDEZ PÉREZ
SANOFI GERMANY, Frankfurt, Germany
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Flow-enabled Synthesis of Fluorinated and Fluoroalkylated Moieties

Prof. Timothy NOËL
Prof. Timothy NOËL
UNIVERSITY OF AMSTERDAM, Amsterdam, The Netherlands

Synthesis of Glycosylated Natural Products or Analogues of Biological Interest

Dr Stéphanie NORSIKIAN
Dr Stéphanie NORSIKIAN
INSTITUT DE CHIMIE DES SUBSTANCES NATURELLES, Gif-sur-Yvette, France

Phenotypic Screen to NLRP3 lead

Dr Daniel OEHLRICH
Dr Daniel OEHLRICH
JOHNSON & JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT, Beerse, Belgium

Finerenone - A Novel Mineralo-Corticoid Receptor (MR) Antagonist

Dr Johannes PLATZEK
Dr Johannes PLATZEK
BAYER, Wuppertal, Germany
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Challenges and Opportunities in CNS Drug Discovery

Dr Frauke POHLKI
Dr Frauke POHLKI
ABBVIE DEUTSCHLAND GMBH & CO.KG, Ludwigshafen, Germany

Covalent Chemical Biology with Natural Products and Novel Synthetic Warheads

Prof. Thomas POULSEN
Prof. Thomas POULSEN
AARHUS UNIVERSITY, Aarhus C, Denmark
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Enabling Technologies to Drive the MSD Portfolio

Dr Rebecca RUCK
Dr Rebecca RUCK
MERCK, SHARP & DOHME, Rahway, United States
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Novel Methods and Strategies for Rapid and Controlled Synthesis of Complex Antibiotics

Prof. David SARLAH
Prof. David SARLAH
UNIVERSITY OF ILLINOIS, Urbana, United States
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Machine Learning to Accelerate Design-Make-Test Cycles

Dr Marwin SEGLER
Dr Marwin SEGLER
MICROSOFT RESEARCH, Cambridge, United Kingdom

Natural Product Synthesis Through the Lens of Informatics

Prof. Ryan SHENVI
Prof. Ryan SHENVI
SCRIPPS RESEARCH, La Jolla, United States

Discovery of the First Orally Efficacious Small Molecules Disrupting the YAP-TEAD Interaction by Direct Competition

Dr Nicolas SOLDERMANN
Dr Nicolas SOLDERMANN
NOVARTIS, Basel, Switzerland

Taking Molecular Glue Degraders to New Heights

Dr Owen WALLACE
Dr Owen WALLACE
MONTE ROSA THERAPEUTICS, Boston, United States
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EFMC Prize for a Young Medicinal Chemist or Chemical Biologist in Academia

Dr Georg WINTER
Dr Georg WINTER
RESEARCH CENTER FOR MOLECULAR MEDICINE OF THE AUSTRIAN ACADEMY OF SCIENCES, Vienna, Austria