EFMC-ASMC 2023

IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry

 Zagreb, Croatia    September 3-7, 2023

Programme


15:30

Registration

17:10

Opening Ceremony

Dr Vesna GABELICA MARKOVIC
CROATIAN CHEMICAL SOCIETY, MEDICINAL & PHARMACEUTICAL CHEMISTRY SECTION, Zagreb, Croatia
Prof. Karl GADEMANN
UNIVERSITY OF ZÜRICH, Zürich, Switzerland
Dr Ingo HARTUNG
MERCK HEALTHCARE, Darmstadt, Germany
Prof. Rui MOREIRA
UNIVERSITY OF LISBON, Lisbon, Portugal
17:30

Opening Lecture
Synthetic and Medicinal Chemistry for Biologics (IL01)

Prof. Jeffrey BODE
ETH ZURICH, Zürich, Switzerland
18:30

Welcome Reception

08:00

Registration

Session 1

Session Chair

Dr Luc VAN HIJFTE
SYMERES, Nijmegen, The Netherlands
08:30

Innovation in Synthetic Fluorine Chemistry through Use of Flow (IL02)

Prof. Timothy NOËL
UNIVERSITY OF AMSTERDAM, Amsterdam, The Netherlands
09:15

MicroCycle: A Machine Learning Driven, Automated and Integrated Platform for Drug Discovery (IL03)

Dr Cara BROCKLEHURST
NOVARTIS, Basel, Switzerland
10:00

Divergent Synthesis as an Emergent Tool for Drug Discovery (OC01)

Prof. Alexandros ZOGRAFOS
ARISTOTLE UNIVERSITY OF THESSALONIK, THESSALONIKI, Greece
10:15

Coffee-break and Exhibition

10:45

Synthesis of Fluorinated Molecules Using Modern Synthetic Tools (IL04)

Dr Tatiana BESSET
INSA OF ROUEN, Mont-Saint-Aignan, France
11:30

Chemical Probes and their Relevance for Drug Discovery Programs – Examples from the Endocannabinoid System (IL05)

Dr Uwe GRETHER
F. HOFFMANN-LA ROCHE, Basel, Switzerland
12:15

Isolation and Biological Activities of Natural Products and Analogues from the Adriatic Coral Eunicella Cavolini (OC02)

Prof. Dean MARKOVIC
UNIVERSITY OF RIJEKA, Rijeka, Croatia
12:30

Lunch and Exhibition

13:15

Poster Session 1

Session 2

Session Chair

Dr Sanja KOSTRUN
SELVITA LTD., Zagreb, Croatia
14:30

New Catalytic Approaches for Simplifying Complex Amine Synthesis (IL06)

Prof. Darren J. DIXON
UNIVERSITY OF OXFORD, Oxford, United Kingdom
15:15

Challenges and Opportunities in CNS Drug Discovery (IL07)

Dr Frauke POHLKI
ABBVIE, Ludwigshafen, Germany
16:00

Design and Optimization of High Performance KSPi ADCs With Increased Tumor Selectivity: Enhancing the Therapeutic Window by Legumain-Mediated ADC Activation (OC03)

Dr Anne-Sophie REBSTOCK
VINCERX, Monheim am Rhein, Germany
16:15

Coffee-break and Exhibition

16:45

Enabling Technologies to Drive the MSD Portfolio (IL08)

Dr Rebecca RUCK
MERCK, SHARP & DOHME, Rahway, United States
17:30

Empowering Organic Synthesis: From Unique Methods to Complex Natural Products (IL09)

Prof. David SARLAH
UNIVERSITY OF ILLINOIS, Urbana, United States
18:15

Closing of the day

Session 3

Session Chair

Prof. Maria Laura BOLOGNESI
UNIVERSITY OF BOLOGNA, Bologna, Italy
08:30

Making Difficult-to-Make Molecules: Photochemistry as an Enabling Tool (IL25)

Dr Susannah COOTE
UNIVERSITY OF BATH, Bath, United Kingdom
09:15

Structure Based Identification of Novel Albumin Binders for Half-Life Extensions of Proteins and Peptides (IL11)

Dr Maria MÉNDEZ PÉREZ
SANOFI-AVENTIS DEUTSCHLAND GMBH, Frankfurt, Germany
10:00

High-Throughput Protac Synthesis and Direct to Biology Assaying for Rapidly Evaluating Targeted Protein Degradation (OC04)

Dr Afjal MIAH
GLAXOSMITHKLINE, Stevenage, United Kingdom
10:15

Coffee-break and Exhibition

10:45

Phenotypic Screen to NLRP3 lead (IL12)

Dr Daniel OEHLRICH
JANSSEN RESEARCH AND DEVELOPMENT, Beerse, Belgium
11:30

Genochemetic Diversification of Natural Products (IL13)

Prof. Rebecca GOSS
UNIVERSITY OF ST ANDREWS, St Andrews, United Kingdom
12:15

Development of Selective mTOR Inhibitors for the Treatment of Cancer and Neurological Disorders (OC05)

Dr Chiara BORSARI
UNIVERSITY OF MILAN, Milan, Italy
12:30

Lunch and Exhibition

13:15

Poster Session 2

Session 4

Session Chair

Dr Ingo HARTUNG
MERCK HEALTHCARE, Darmstadt, Germany
14:30

Next Generation Design-Make-Test-Analysis-Cycles (IL14)

Dr Clara CHRIST
BAYER, Berlin, Germany
15:15

Making and Breaking of C-S Bonds Using Metal Catalysis (IL15)

Dr Ivana FLEISCHER
UNIVERSITY OF TÜBINGEN, Tuebingen, Germany
16:00

Discovery of Imidazo[1,2-a]Pyridine Carboxamide BAY 1165747, a Long-Acting Soluble Guanylate Cyclase Stimulator for Resistant Hypertension (OC06)

Dr Alexandros VAKALOPOULOS
BAYER, Wuppertal, Germany
16:15

Coffee-break and Exhibition

16:45

From BRD4 to KRAS: 12 Years of Oncology Small Molecules (IL16)

Dr Darryl MCCONNELL
BOEHRINGER INGELHEIM, Austria
17:30

Synthesis of Glycosylated Natural Products or Analogues of Biological Interest (IL17)

Dr Stéphanie NORSIKIAN
INSTITUT DE CHIMIE DES SUBSTANCES NATURELLES, Gif-sur-Yvette, France
18:15

Closing of the day

Session 5

Session Chair

Dr Werngard CZECHTIZKY
ASTRAZENECA, Mölndal, Sweden
08:30

Machine Learning to Accelerate Design-Make-Test Cycles (IL18)

Dr Marwin SEGLER
MICROSOFT RESEARCH, Cambridge, United Kingdom
09:15

Covalent Chemical Biology with Natural Products and Novel Synthetic Warheads (IL19)

Prof. Thomas POULSEN
AARHUS UNIVERSITY, Aarhus C, Denmark
10:00

Direct Access to Unnatural Drug-Like Molecules by Photocatalytic Late-Stage Functionalization (OC07)

Prof. Olga GARCIA MANCHENO
UNIVERSITY OF MÜNSTER, Münster, Germany
10:15

Coffee-break and Exhibition

10:45

Multicomponent Alkene Cross-Coupling by Base Metal Catalysis (IL20)

Dr Ming Joo KOH
NATIONAL UNIVERSITY OF SINGAPORE, Singapore, Singapore
11:30

Novel, Reversible DCAF1 Ligands Expand the TPD-Toolbox (IL21)

Dr Martin SCHRÖDER
NOVARTIS, Basel, Switzerland
Dr Anna VULPETTI
NOVARTIS, Basel, Switzerland
12:15

Cocktails For 19F NMR Fragment Screening: From Theory to Applications Using Enamine’s Stock Chemical Space (OC08)

Prof. Dmytro VOLOCHNYUK
ENAMINE LTD, Kyiv, Ukraine
12:30

Lunch and Exhibition

13:15

Poster Session 3

Session 6

Session Chair

Prof. Rui MOREIRA
UNIVERSITY OF LISBON, Lisbon, Portugal
14:30

Disrupting the YAP-TEAD Protein-Protein Interaction with Small Molecules - Discovery of Drug Candidate NVP-IAG933 (IL22)

Dr Nicolas SOLDERMANN
NOVARTIS, Basel, Switzerland
15:15

EFMC Prizes Session - Ceremony & Lectures

15:20

EFMC Prize for a Young Medicinal Chemist or Chemical Biologist in Academia
Targeted Protein Degradation via Molecular Glues (PR01)

Dr Georg WINTER
RESEARCH CENTER FOR MOLECULAR MEDICINE OF THE AUSTRIAN ACADEMY OF SCIENCES, Vienna, Austria
15:35

EFMC Prize for a Young Medicinal Chemist or Chemical Biologist in Industry
Discovery and Characterization of Potent, Efficacious and Orally Available Antimalarial Plasmepsin X Inhibitors (PR02)

Dr Teresa DE HARO GARCIA
UCB, Braine l'Alleud, Belgium
15:50

EFMC-YMCS 2022 Best Oral Communication (OC09)
Epitope Identification Using In-Silico Approaches, a Case Study: Nanobodies Binding to MGlu5 Receptor

Ms Floriane ESHAK
UNIVERSITY PARIS CITÉ, Paris, France
16:05

EFMC Best Practices Working Group

Prof. Anders BACH
UNIVERSITY OF COPENHAGEN, Copenhagen, Denmark
16:15

Coffee-break and Exhibition

16:45

First time disclosure
Discovery of the clinical candidate BI 1810631 (Zongertinib), a Selective HER2 Inhibitor for the Treatment of HER2 Exon 20 Insertion Driven Tumors (OC10)

Dr Birgit WILDING
BOEHRINGER INGELHEIM, Vienna, Austria
17:10

Will Chemputers Dream of Electric Drugs (IL23)

Prof. Leroy CRONIN
UNIVERSITY OF GLASGOW, Glasgow, United Kingdom
17:55

Closing of the day

20:00

Symposium Banquet sponsored by Selvita

Session 7

Session Chair

Prof. Karl GADEMANN
UNIVERSITY OF ZÜRICH, Zürich, Switzerland
08:30

Taking Molecular Glue Degraders to New Heights (IL24)

Dr Etienne DONCKELE
MONTE ROSA THERAPEUTICS, Basel, Switzerland
09:15

The beautiful simplicity of rearrangements – towards ideal reactions? (IL10)
Chemistry Europe Speaker

Prof. Nuno MAULIDE
UNIVERSITY OF VIENNA, Vienna, Austria
10:00

RSC Medicinal Chemistry Lectureship
Time to Shine for Constrained Peptides in Medicinal Chemistry (OC11)

Prof. Christoph NITSCHE
AUSTRALIAN NATIONAL UNIVERSITY, Canberra, Australia
10:15

Coffee-break and Exhibition

10:45

Novel Modes of Enzyme Inhibition (IL26)

Dr Anders JOHANSSON
ASTRAZENECA, Molndal, Sweden
11:30

Natural Product Synthesis Through the Lens of Informatics (IL27)

Prof. Ryan SHENVI
SCRIPPS RESEARCH, La Jolla, United States
12:15

Closing Remarks & Prize Ceremony

Prof. Karl GADEMANN
UNIVERSITY OF ZÜRICH, Zürich, Switzerland
12:30

End of the symposium