EFMC-ASMC 2023

IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry

 Zagreb, Croatia    September 3-7, 2023

Programme


15:30

Registration

17:00

Opening

17:30

Opening Lecture
Synthetic and Medicinal Chemistry for Biologics

Prof. Jeffrey BODE
ETH ZURICH, Zürich, Switzerland
18:30

Welcome Reception

08:00

Registration

08:30

Flow-enabled Synthesis of Fluorinated and Fluoroalkylated Moieties

Prof. Timothy NOËL
UNIVERSITY OF AMSTERDAM, Amsterdam, The Netherlands
09:15

MicroCycle: A Machine Learning Driven, Automated and Integrated Platform for Drug Discovery

Dr Cara BROCKLEHURST
NOVARTIS, Basel, Switzerland
10:00

OC01 - Divergent Synthesis as an Emergent Tool for Drug Discovery

Prof. Alexandros ZOGRAFOS
ARISTOTLE UNIVERSITY OF THESSALONIK, THESSALONIKI, Greece
10:15

Coffee-break and Exhibition

10:45

Synthesis of Fluorinated Molecules Using Modern Synthetic Tools

Dr Tatiana BESSET
INSA OF ROUEN, Mont-Saint-Aignan, France
11:30

Chemical Probes and their Relevance for Drug Discovery Programs – Examples from the Endocannabinoid System

Dr Uwe GRETHER
F. HOFFMANN-LA ROCHE, Basel, Switzerland
12:15

OC02 - Isolation and Biological Activities of Natural Products and Analogues from the Adriatic Coral Eunicella Cavolini

Prof. Dean MARKOVIć
UNIVERSITY OF RIJEKA, Rijeka, Croatia
12:30

Lunch and Exhibition

14:00

New Catalytic Approaches for Simplifying Complex Amine Synthesis

Prof. Darren J. DIXON
UNIVERSITY OF OXFORD, Oxford, United Kingdom
14:45

Challenges and Opportunities in CNS Drug Discovery

Dr Frauke POHLKI
ABBVIE DEUTSCHLAND GMBH & CO.KG, Ludwigshafen, Germany
15:30

OC03 - Design and Optimization of High Performance KSPi ADCs With Increased Tumor Selectivity: Enhancing the Therapeutic Window by Legumain-Mediated ADC Activation

Dr anne-sophie REBSTOCK
VINCERX, monheim am rhein, Germany
15:45

Coffee-break and Exhibition

16:15

Enabling Technologies to Drive the MSD Portfolio

Dr Rebecca RUCK
MERCK, SHARP & DOHME, Rahway, United States
17:00

Novel Methods and Strategies for Rapid and Controlled Synthesis of Complex Antibiotics

Prof. David SARLAH
UNIVERSITY OF ILLINOIS, Urbana, United States
17:45

Closing of the day

08:30

Can Chemistry Generate Biological Questions?

Prof. Nuno MAULIDE
UNIVERSITY OF VIENNA, Vienna, Austria
09:15

Structure Based Identification of Novel Albumin Binders for Half-Life Extensions of Proteins and Peptides

Dr Maria MÉNDEZ PÉREZ
SANOFI GERMANY, Frankfurt, Germany
10:00

OC04 - High-Throughput Protac Synthesis and Direct to Biology Assaying for Rapidly Evaluating Targeted Protein Degradation

Dr Afjal MIAH
GLAXOSMITHKLINE, Stevenage, United Kingdom
10:15

Coffee-break and Exhibition

10:45

Phenotypic Screen to NLRP3 lead

Dr Daniel OEHLRICH
JOHNSON & JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT, Beerse, Belgium
11:30

Precision Molecule Editing (a Game of Bio and Chemo-catalysis)

Prof. Rebecca GOSS
UNIVERSITY OF ST ANDREWS, St Andrews, United Kingdom
12:15

OC05 - Discovery of A Potent, Selective and Metabolically Stable mTOR Kinase Inhibitor Exploiting Morpholine Isosters

Dr Chiara BORSARI
UNIVERSITY OF MILAN, Milan, Italy
12:30

Lunch and Exhibition

13:30

Poster Session 1 (odd numbers)

14:30

Next Generation Design-Make-Test-Analysis-Cycles

Dr Clara CHRIST
BAYER, Berlin, Germany
15:15

Making and Breaking of C-S Bonds Using Metal Catalysis

Dr Ivana FLEISCHER
UNIVERSITY OF TÜBINGEN, Tuebingen, Germany
16:00

OC06 - Discovery of Imidazo[1,2-a]Pyridine Carboxamide BAY 1165747, a Long-Acting Soluble Guanylate Cyclase Stimulator for Resistant Hypertension

Dr Alexandros VAKALOPOULOS
BAYER AG, Wuppertal, Germany
16:15

Coffee-break and Exhibition

16:45

From BRD4 to KRAS: 12 Years of Oncology Small Molecules

Dr Darryl MCCONNELL
BOEHRINGER INGELHEIM, Vienna, Austria
17:30

Synthesis of Glycosylated Natural Products or Analogues of Biological Interest

Dr Stéphanie NORSIKIAN
INSTITUT DE CHIMIE DES SUBSTANCES NATURELLES, Gif-sur-Yvette, France
18:15

Closing of the day

08:30

Machine Learning to Accelerate Design-Make-Test Cycles

Dr Marwin SEGLER
MICROSOFT RESEARCH, Cambridge, United Kingdom
09:15

Covalent Chemical Biology with Natural Products and Novel Synthetic Warheads

Prof. Thomas POULSEN
AARHUS UNIVERSITY, Aarhus C, Denmark
10:00

OC07 - Direct Access to Unnatural Drug-Like Molecules by Photocatalytic Late-Stage Functionalization

Prof. Olga GARCIA MANCHENO
UNIVERSITY OF MÜNSTER, Münster, Germany
10:15

Coffee-break and Exhibition

10:45

Multicomponent Alkene Cross-Coupling by Base Metal Catalysis

Dr Ming Joo KOH
NATIONAL UNIVERSITY OF SINGAPORE, Singapore, Singapore
11:30

Finerenone - A Novel Mineralo-Corticoid Receptor (MR) Antagonist

Dr Johannes PLATZEK
BAYER, Wuppertal, Germany
12:15

OC08 - Cocktails For 19F NMR Fragment Screening: From Theory to Applications Using Enamine’s Stock Chemical Space

Prof. Dmytro VOLOCHNYUK
ENAMINE LTD, Kyiv, Ukraine
12:30

Lunch and Exhibition

13:30

Poster Session 2 (even numbers)

14:30

Discovery of the First Orally Efficacious Small Molecules Disrupting the YAP-TEAD Interaction by Direct Competition

Dr Nicolas SOLDERMANN
NOVARTIS, Basel, Switzerland
15:15

EFMC Prizes Session - Ceremony & Lectures

15:20

EFMC Prize for a Young Medicinal Chemist or Chemical Biologist in Academia

Dr Georg WINTER
RESEARCH CENTER FOR MOLECULAR MEDICINE OF THE AUSTRIAN ACADEMY OF SCIENCES, Vienna, Austria
15:35

EFMC Prize for a Young Medicinal Chemist or Chemical Biologist in Industry

Dr Teresa DE HARO GARCIA
UCB, Braine l'Alleud, Belgium
15:50

EFMC Prize Winner EFMC-YMCS 2022

Ms Floriane ESHAK
UNIVERSITY PARIS CITÉ, Paris, France
16:05

Coffee-break and Exhibition

16:35

Why Chemputers Will Dream of Electric Drugs

Prof. Leroy CRONIN
UNIVERSITY OF GLASGOW, Glasgow, United Kingdom
17:20

Closing of the day

20:00

Symposium Banquet sponsored by Selvita

08:30

Taking Molecular Glue Degraders to New Heights

Dr Owen WALLACE
MONTE ROSA THERAPEUTICS, Boston, United States
09:15

Making Difficult-to-Make Molecules: Photochemistry as an Enabling Tool

Dr Susannah COOTE
UNIVERSITY OF BATH, Bath, United Kingdom
10:00

OC09

10:15

Coffee-break and Exhibition

10:45

Novel Modes of Enzyme Inhibition

Dr Anders JOHANSSON
ASTRAZENECA, Molndal, Sweden
11:30

Natural Product Synthesis Through the Lens of Informatics

Prof. Ryan SHENVI
SCRIPPS RESEARCH, La Jolla, United States
12:15

Closing Remarks & Prize Ceremony

12:30

End of the symposium